The number of infections across the country also shot up to 24,926, the health ministry said in a statement.
The capital Madrid remains the hardest hit in the country, according to the tally reported by the ministry.
The new numbers follow a fresh spike in both deaths and infections on Friday.
Spain has issued lockdown orders for some 46 million people who are only permitted to leave their homes for essential work, food shopping, medical reasons or to walk the dog.
Italy is Europe’s worst affected country in terms of the death toll, followed by Spain and France.